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首页> 外国专利> METHOD OF CHOOSING THE STRATEGY OF REVISION ENDOPROSTHESIS REPLACEMENT OF LARGE JOINTS

METHOD OF CHOOSING THE STRATEGY OF REVISION ENDOPROSTHESIS REPLACEMENT OF LARGE JOINTS

机译：大型关节内翻置换术选择策略的方法

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FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to traumatology and laboratory diagnostics, and can be used for selection of tactic of revision endoprosthesis replacement of large joints. Method involves conducting a laboratory examination of the synovial fluid samples from the joints subjected to revision endoprosthesis. Additionally, the synovial fluid samples are taken from an intact large joint. Use of local anesthesia and blood ingestion during sampling of the puncture needle is excluded. Method includes determining in all samples an expression level α-defensins HNP-1, HNP-2, HNP-3. If expression ratio is detected α-defensins HNP-1, HNP-2, HNP-3 in the operated and intact joints 2:1 and higher, the presence of infection of the operated joint is evaluated, and a two-stage revision endoprosthesis replacement with the antibacterial joint spacer installation is prescribed. If expression ratio is detected α-defensins HNP-1, HNP-2, HNP-3 in the operated and intact joints less than 2:1, the absence of infection of the operated joint is determined, and one-stage revision endoprosthesis is prescribed.;EFFECT: invention provides more accurate selection of the proposed surgical management based on a comparative assessment of the level α-defensins HNP-1, HNP-2, HNP-3 in intact and operated joints.;1 cl, 6 dwg, 2 ex
机译：技术领域本发明涉及医学，即指创伤学和实验室诊断学，并且可以用于选择大关节翻修假体的策略。方法包括对接受翻修内假体的关节的滑液样本进行实验室检查。此外，滑液样本取自完整的大关节。排除在穿刺针取样期间使用局部麻醉和血液摄入的情况。方法包括在所有样品中确定表达水平α-防御素HNP-1，HNP-2，HNP-3。如果在手术和完整关节中以2：1或更高的比率检测到α-防御素HNP-1，HNP-2，HNP-3的表达率，则评估手术关节是否存在感染，并进行两阶段翻修术规定必须安装抗菌接头垫片。如果在手术和完整关节中检测到的α-防御素HNP-1，HNP-2，HNP-3的表达率小于2：1，则确定没有感染手术关节，并开具一阶段翻修假体效果：本发明基于对完整和手术关节中α-防御素HNP-1，HNP-2，HNP-3水平的比较评估，可以更准确地选择拟议的手术方法; 1 cl，6 dwg，2前

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