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首页> 外国专利> METHOD FOR DIFFERENTIAL DIAGNOSTICS OF ODDI SPHINCTER DYSFUNCTION

METHOD FOR DIFFERENTIAL DIAGNOSTICS OF ODDI SPHINCTER DYSFUNCTION

机译：ODDI括约肌功能异常的鉴别诊断方法

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FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to functional diagnostics and gastroenterology, and can be used for differential diagnosis of organic and functional changes of sphincter of Oddi. That is ensured by direct measurement of pressure in the bile ducts, which is measured before and after four successive infusions of contrast agent 50 % p-p of Ultravist with strictly preset rate and volume, and subsequent calculation of pressure gradient: 4 ml/min for 5 minutes; 8 ml/min – 5 min; 15 ml/min – 3 min; 20 ml/min – 2 minutes. If the initial pressure is higher than 200 mm of water column before the test, the result of the test is considered to be negative and further analysis is not carried out. If intra-lateral pressure gradient exceeds 200 mm of water column during more than one infusion, test result is also considered to be negative. If the pressure gradient after introduction of the solution does not exceed 200 mm of water column, the result of the test is considered to be positive. In case of positive result of direct measurement of pressure in bile ducts, a pharmacological test is additionally carried out by administering 20 mg of buscopan or 5 mg of platiphyllin with subsequent repeated testing in 60 minutes according to above described sequence at threshold level of pressure gradient of 150 mm of water column. If observing stable manometry results accompanying spasmolytics introduction, organic involvement of bile ducts is diagnosed. If the manometry results change taking into account the threshold level of the pressure gradient of 150 mm of water column in response to the introduction of antispasmodic, dyskinesia of bile ducts is diagnosed.;EFFECT: method provides optimizing the choice of therapeutic approach to the patients in this category.;1 cl, 2 ex
机译：技术领域本发明涉及医学，即功能诊断学和肠胃病学，可以用于对Oddi括约肌的器质性和功能性变化进行鉴别诊断。通过直接测量胆管中的压力来确保这一点，该压力是在四次连续注入50％pp的Ultravist造影剂前后严格测量的，并预先设定了速率和体积，然后计算压力梯度：5毫升/分钟为4毫升/分钟分钟; 8 ml / min – 5分钟; 15 ml / min – 3分钟; 20 ml / min – 2分钟。如果测试前的初始压力高于水柱的200 mm，则测试结果为负值，因此不进行进一步分析。如果在多次输注过程中，侧内压力梯度超过水柱的200 mm，则测试结果也被视为阴性。如果引入溶液后的压力梯度不超过200 mm水柱，则测试结果为阳性。如果直接测量胆管中压力的阳性结果，则另外进行药理学测试，方法是：按上述顺序在压力梯度阈值水平下，按照上述顺序在20分钟内给予20 mg buscopan或5 mg platiphyllin进行随后的重复测试150毫米水柱。如果观察到稳定的测压结果并伴有解痉剂的引入，则可诊断为胆管有机累及。如果考虑到解痉痉挛而考虑到150 mm水柱压力梯度的阈值水平而导致测压结果发生变化，则诊断为胆管运动障碍;;效果：该方法为患者提供了最佳治疗方法选择在该类别中。; 1 cl，2 ex

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