首页> 外国专利> METHOD FOR PREDICTION OF CLINICAL COURSE OF SCHIZOPHRENIA IN MEN WITH PAROXYSMAL ENDOGENOUS PSYCHOSES MANIFESTING AT AGE FROM 18 TO 25 YEARS

METHOD FOR PREDICTION OF CLINICAL COURSE OF SCHIZOPHRENIA IN MEN WITH PAROXYSMAL ENDOGENOUS PSYCHOSES MANIFESTING AT AGE FROM 18 TO 25 YEARS

机译:预测阵发性内源性精神分裂症在18至25岁年龄段的男性中精神分裂症的临床课程的方法

摘要

FIELD: medicine.;SUBSTANCE: invention refers to psychiatry, and represents a method for prediction of clinical course of schizophrenia in men with paroxysmal endogenous psychoses manifesting at age from 18 to 25 years, method involves assessing the patient's functioning level in the period preceding the onset of the disease by the premorbidity functioning scale (PAS), characterized by that when evaluating premorbid functioning (PAS) in range of 0.23 to 0.5 points and higher, a biological material is selected in the patient, DNA is extracted from it, variants of polymorphic loci of 5-HTTLPR of the serotonin transporter gene, Val66Met of the neurotrophic cerebral factor gene (BDNF), T102C gene of serotonin receptor type 2A (5-HTR2A) and a combination of versions of genes predicting the course of schizophrenia, wherein if LL (5-HTTLPR), or Met (Val66Met), or CC (T102C) is present in the combination, an unfavorable clinical course is predicted, while a SValValT combination shows a favorable course of schizophrenia.;EFFECT: due to the quantitative assessment of the risk of the unfavorable course of the disease, the more accurate prediction of clinical course of schizophrenia in the early stages of men with the onset of endogenous psychoses manifesting at age of 18 to 25 years due to the use of information on the genetically determined characteristics of the patient.;1 cl, 7 ex
机译:技术领域本发明涉及精神病学,并且代表一种用于预测表现为阵发性内源性精神病的18至25岁男性精神分裂症临床病程的方法,该方法包括评估患者在精神分裂症之前的功能水平。通过发病前功能量表(PAS)来确定疾病的发作,其特征在于,当评估发病前功能量(PAS)的范围为0.23至0.5点或更高时,在患者中选择一种生物材料,从中提取DNA,血清素转运蛋白基因5-HTTLPR的多态性基因座,神经营养性脑因子基因(BDNF)的Val66Met,血清素2A型(5-HTR2A)的T102C基因以及预测精神分裂症病程的基因版本的组合,其中如果组合中存在LL(5-HTTLPR)或Met(Val66Met)或CC(T102C),预计临床过程不利,而SValValT组合显示出有利的作用精神分裂症的病程;效果:由于对疾病的不利病程的风险进行了定量评估,因此对于18岁以下内源性精神病发作的男性,早期阶段的精神分裂症临床病程的预测更加准确到25年,因为使用了有关患者遗传特征的信息。; 1 cl,7 ex

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