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首页> 外国专利> RECOMBINANT INFLUENZA VIRUS STRAIN A/PR8/HK-NS80E85A, EXPRESSING FRAGMENTS OF ESAT-6 AND AG85A MYCOBACTERIUM TUBERCULOSIS ANTIGENS, TO OBTAIN TUBERCULOSIS VECTORED VACCINE

RECOMBINANT INFLUENZA VIRUS STRAIN A/PR8/HK-NS80E85A, EXPRESSING FRAGMENTS OF ESAT-6 AND AG85A MYCOBACTERIUM TUBERCULOSIS ANTIGENS, TO OBTAIN TUBERCULOSIS VECTORED VACCINE

机译：重组流感病毒株A / PR8 / HK-NS80E85A，表达ESAT-6和AG85A结核分枝杆菌抗原片段，获得结核分枝杆菌疫苗

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FIELD: medicine; biotechnology.;SUBSTANCE: using the reverse genetics method, a recombinant strain of influenza virus A/PR8/HK-NS80E85A was obtained, which is attenuated, cold-adapted, temperature-sensitive, and expresses fragments of the ESAT6 and Ag85A antigens of M. tuberculosis. Recombinant strain A/PR8/HK-NS80E85A is genetically stable and has a high reproductive activity in the system of developing chick embryos, and also stimulates a specific antituberculous CD4+ T-cell response of Th1 type with the formation of polyfunctional antigen-specific T-cells when administered intranasally to mice. This recombinant strain A/PR8/HK-NS80E85A was deposited in the State collection of viruses of Honorary academician N. F. Gamaleya National Research Center for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation under No. 2863.;EFFECT: invention can be used to obtain a tuberculosis vectored vaccine.;1 cl, 7 dwg, 4 tbl, 5 ex
机译：领域：医学;物质：使用逆向遗传学方法，获得了重组的流感病毒A / PR8 / HK-NS80E85A菌株，该菌株经过减毒，冷适应，对温度敏感，并表达M的ESAT6和Ag85A抗原片段结核病重组菌株A / PR8 / HK-NS80E85A具有遗传稳定性，并且在发育中的雏鸡胚胎系统中具有很高的繁殖活性，并且还刺激Th1型特异性抗结核CD4 + T细胞反应，并形成多功能抗原特异性T-经鼻内给药给小鼠的细胞。该重组菌株A / PR8 / HK-NS80E85A存放在俄罗斯联邦卫生部名誉教授N.F. Gamaleya国家流行病学和微生物学研究中心的国家病毒库中，编号2863。本发明可用于获得结核病载体疫苗。; 1 cl，7 dwg，4 tbl，5 ex

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