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首页> 外国专利> METHOD OF DIAGNOSTICS OF RECURRENT BRONCHITIS ASSOCIATED WITH THE IMPACT OF FINE DUST IN CHILDREN

METHOD OF DIAGNOSTICS OF RECURRENT BRONCHITIS ASSOCIATED WITH THE IMPACT OF FINE DUST IN CHILDREN

机译：儿童细粉尘影响的复发性支气管炎的诊断方法

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FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to pulmonology and toxicology. On the territory of the average daily content of fine dust, 1.6 or more times the maximum permissible concentration, children with recurrent bronchitis are detected. Functional characteristics of the child are determined: the respiratory impedance Zrs and its resistive resistance Rrs and the reactance Xrs in the frequency range of 5–35 Hz, as well as the index of the resonant frequency Fr. As laboratory parameters set: the content of lymphocytes; eosinophilic lymphocytic index; the content of CD 19+ and CD56+ lymphocytes; the level of blood serum antioxidant activity (AO A); malondialdehyde (MDA) level; lipid hydroperoxide level; superoxide dismutase level (Cu/Zn-SOD); the content of immunoglobulin A (IgA) and the content of immunoglobulin E (IgE); phagocytosis indicators: phagocytic number, phagocytic index. With an increase, compared with the norm, the respiratory impedance Zrs, with a decrease in the reactance Xrs by not less than 15 % and an increase in the resistive resistance Rrs by not less than 20 %, with an increase in the resonant frequency Fr, as well as when exceeding the norm: the content of CD 19+ lymphocytes by 15 % or more; eosinophilic lymphocytic index 2.0 times or more; the level of MDA in 1.5 times or more; the lipid hydroperoxide level in 1.2 times or more; IgA content of at least 15 %; the content of IgE more than 1.5 times; phagocytic number and phagocytic index of more than 1.2 times; and a decrease relative to the age physiological norm: the content of lymphocytes in 1.3 times or more; the content of CD56+ lymphocytes by 15 % or more; AOA level not less than 1.5 times; the level of Cu/Zn-SOD at least 1.2 times, recurrent bronchitis associated with exposure to fine dust is diagnosed in a child.;EFFECT: method allows informatively and conclusively diagnosing recurrent bronchitis associated with exposure to fine dust to prescribe adequate therapy in the early stages of the disease and prevent the development of complications by evaluating a set of the most significant indicators.;1 cl, 3 tbl, 1 ex
机译：技术领域本发明涉及医学，即涉及肺病学和毒理学。在每天平均细粉尘含量（最大允许浓度的1.6倍或更多）的范围内，检测出患有复发性支气管炎的儿童。确定孩子的功能特征：在5–35 Hz频率范围内的呼吸阻抗Zrs及其电阻Rrs和电抗Xrs，以及谐振频率Fr的指数。作为实验室参数设置：淋巴细胞的含量;嗜酸性淋巴细胞指数; CD 19+和CD56 +淋巴细胞的含量;血清抗氧化活性水平（AO A）;丙二醛（MDA）含量;脂质氢过氧化物水平;超氧化物歧化酶水平（Cu / Zn-SOD）;免疫球蛋白A（IgA）和免疫球蛋白E（IgE）的含量;吞噬指标：吞噬数，吞噬指数。与标准相比，呼吸阻抗Zrs增大，电抗Xrs减小不小于15％，电阻抗Rrs增大不小于20％，谐振频率Fr增大，以及超出正常水平时：CD 19+淋巴细胞的含量增加15％或更多;嗜酸性淋巴细胞指数2.0倍或更高;丙二醛水平在1.5倍或以上;脂质氢过氧化物水平在1.2倍以上; IgA含量至少为15％; IgE的含量超过1.5倍;吞噬数和吞噬指数超过1.2倍;且相对于年龄生理标准而言降低：淋巴细胞的含量是1.3倍或更高; CD56 +淋巴细胞的含量在15％以上; AOA水平不少于1.5倍;铜/锌超氧化物歧化酶水平至少为儿童确诊的反复细支气管炎的1.2倍;效果：该方法可以提供有益的结论性诊断与细尘接触的复发性支气管炎，以便在儿童中规定适当的治疗方法疾病的早​​期阶段，并通过评估一组最重要的指标来预防并发症的发展。; 1 cl，3 tbl，1 ex

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