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首页> 外国专利> Method for early prediction of the risk of motor impairment in premature infants born with low and extremely low body mass with perinatal hypoxic-ischemic brain lesions

Method for early prediction of the risk of motor impairment in premature infants born with low and extremely low body mass with perinatal hypoxic-ischemic brain lesions

机译：围产期缺氧缺血性脑病的低体重和极低体重早产儿运动障碍风险早期预测方法

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FIELD: medicine.SUBSTANCE: invention refers to paediatrics, neonatology, neurology and radiodiagnosis, and can be used for early prediction of motor disturbance risk in premature newborns born with low and extremely low body weight, with perinatal hypoxic-ischemic cerebral lesions. Magnetic resonance tomography of the brain is performed in the diffusion-tensor mode at 38–40 weeks of the corrected age. Fractional anisotropy values are measured in posterior hip zones of internal capsules of both cerebral hemispheres. If fractional anisotropy in both hemispheres is 0.280 and more, a low degree of risk of developing motor disturbances by the end of the first year of life of the child is determined. If in one or both hemispheres the values of fractional anisotropy are 0.230 to 0.280, the average degree of risk of developing motor disturbances is determined. If the value of fractional anisotropy is 0.229 and less, at least in one or both hemispheres, a high risk of developing motor disturbances is determined.EFFECT: method provides higher accuracy of early diagnosis of the risk of developing motor disorders by the end of the first year of life in children born with low and extremely low body weight, timely updating of the management tactics and development of rehabilitation programs taking into account the risk of motor disorders in this group of children, as well as reduced number of children with motor deficiency and reduced severity of motion disorders by determining values of fractional anisotropy in posterior hip zones of internal capsules of both cerebral hemispheres at 38–40 weeks of corrected age.1 cl, 1 tbl, 4 ex
机译：领域：药物：本发明涉及儿科，新生儿科，神经科和放射诊断，可用于早期预测体重低和极低，围产期缺氧缺血性脑病的早产儿的运动障碍风险。大脑的磁共振断层扫描是在校正年龄的38-40周以扩散张量模式进行的。在两个大脑半球内囊的后髋区测量分数各向异性值。如果两个半球的各向异性分数均大于或等于0.280，则确定在儿童生命的第一年末发生运动障碍的风险较低。如果在一个或两个半球中，分数各向异性的值是0.230至0.280，则确定发生运动障碍的平均风险程度。如果分数各向异性的值至少在一个或两个半球中为0.229以下，则确定发生运动障碍的高风险。效果：该方法可在患病末期早期更准确地诊断运动障碍的风险体重过轻和过低的儿童出生后的第一年，考虑到这类儿童运动障碍的风险以及减少的运动障碍儿童的数量，及时更新管理策略并制定康复计划通过在校正年龄38-40周时确定两个大脑半球内囊后髋区的分数各向异性值来降低运动障碍的严重程度。1cl，1 tbl，4 ex

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