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GLP-1 - CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS

机译:GLP-1-葡聚糖和GLP-1受体的共激动剂

摘要

Equivalent resistance to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and that peptide analogs of glucagon are relatively balanced in glucagon-like peptide 1 (GLP-1) receptors and glucagon (GCG) receptors Peptide analogs of glucacon, modified to increase the in vivo half-life of the peptide analog while allowing it to have activating activity, and metabolic disorders such as diabetes, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis ( NASH) and the use of such GLP-1 receptor / GCG receptor co-agonists for treating obesity.
机译:胰高血糖素样肽1(GLP-1)受体和胰高血糖素(GCG)受体对二肽基肽酶IV(DPP-IV)的切割和失活的等效抗性以及胰高血糖素的肽类似物相对平衡肽类似物的体内半衰期,同时使其具有激活活性,以及​​代谢紊乱,例如糖尿病,非酒精性脂肪肝疾病(NAFLD),非酒精性脂肪性肝炎(NASH)以及使用此类GLP-1受体/ GCG受体肥胖症的辅助激动剂。

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