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GLP-1 - CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS
GLP-1 - CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS
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机译:GLP-1-葡聚糖和GLP-1受体的共激动剂
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摘要
Equivalent resistance to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and that peptide analogs of glucagon are relatively balanced in glucagon-like peptide 1 (GLP-1) receptors and glucagon (GCG) receptors Peptide analogs of glucacon, modified to increase the in vivo half-life of the peptide analog while allowing it to have activating activity, and metabolic disorders such as diabetes, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis ( NASH) and the use of such GLP-1 receptor / GCG receptor co-agonists for treating obesity.
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