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PLGA DRUG-CONTAINING PLGA MICROSPHERES AND THE PREPARATION METHODS THEREOF

机译:含PLGA药物的PLGA微球及其制备方法

摘要

The present invention relates to biodegradable polymeric microspheres containing trametinib and a method for manufacturing the same. Polymeric microspheres of the present invention can be used for manufacturing sustained-release parenteral formulations containing trametinib as an active component. According to the present invention, it is possible to overcome a problem that a hydrophobic drug is not encapsulated in microspheres, but crystallized in an aqueous phase. In addition, it is possible to obtain trametinib-containing polymer microspheres in a good spherical shape and achieve nearly 100% of a drug encapsulation rate.
机译:本发明涉及含有曲美替尼的可生物降解的聚合物微球及其制造方法。本发明的聚合物微球可用于制备含有曲美替尼作为活性成分的缓释肠胃外制剂。根据本发明,可以克服疏水性药物不包封在微球中而是在水相中结晶的问题。另外,可以获得具有良好球形的含曲美替尼的聚合物微球,并实现接近100%的药物包封率。

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