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PLGA DRUG-CONTAINING PLGA MICROSPHERES AND THE PREPARATION METHODS THEREOF
PLGA DRUG-CONTAINING PLGA MICROSPHERES AND THE PREPARATION METHODS THEREOF
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机译:含PLGA药物的PLGA微球及其制备方法
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摘要
The present invention relates to biodegradable polymeric microspheres containing trametinib and a method for manufacturing the same. Polymeric microspheres of the present invention can be used for manufacturing sustained-release parenteral formulations containing trametinib as an active component. According to the present invention, it is possible to overcome a problem that a hydrophobic drug is not encapsulated in microspheres, but crystallized in an aqueous phase. In addition, it is possible to obtain trametinib-containing polymer microspheres in a good spherical shape and achieve nearly 100% of a drug encapsulation rate.
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