首页> 外国专利> . A viral vector for treating and alleviating Parkinson's disease a pharmaceutical composition comprising the same and a method for treating Parkinson's disease.

. A viral vector for treating and alleviating Parkinson's disease a pharmaceutical composition comprising the same and a method for treating Parkinson's disease.

机译:。一种用于治疗和减轻帕金森氏病的病毒载体,包含该病毒载体的药物组合物以及用于治疗帕金森氏病的方法。

摘要

The present invention relates to a viral vector for treating Parkinson′s disease and a method for treating Parkinson′s disease using the same. More specifically, the present invention relates to a method for alleviating and treating behavioral disorders caused by Parkinson′s disease by injecting and expressing the viral vector which expresses halorhodopsin (NpHR) in the cerebral inner core or globus pallidus in a brain region, and activating the same through optical stimulation. The composition and a treatment method of the present invention can alleviate behavioral disorders caused by Parkinson′s disease by a photogenetic method which is a highly targeted and effective method compared to existing drugs or exercise treatment methods.
机译:本发明涉及用于治疗帕金森氏病的病毒载体和使用该病毒载体治疗帕金森氏病的方法。更具体地,本发明涉及通过注射并表达在脑内区域的大脑内核或苍白球中表达卤代视紫红质(NpHR)的病毒载体并活化来减轻和治疗由帕金森氏病引起的行为障碍的方法。通过光刺激相同。本发明的组合物和治疗方法可以通过光遗传学方法减轻由帕金森氏病引起的行为障碍,所述光遗传学方法是与现有药物或运动治疗方法相比高度靶向和有效的方法。

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