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A manipulated multicomponent system for identification and characterization of T-cell receptors and T-cell antigens
A manipulated multicomponent system for identification and characterization of T-cell receptors and T-cell antigens
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机译：一种可操纵的多组分系统，用于鉴定和表征T细胞受体和T细胞抗原
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摘要
The present invention relates to a multi-component system, wherein the first component is a engineered antigen-presenting cell (eAPC) designated component A and the second component is an analyte antigen-presenting complex (aAPX) and / Is a gene donor vector designated as component C for delivery of one or more ORFs encoding the molecule (aAM), wherein component A is: a. lack of endogenous surface expression of at least one family of aAPX and / or aAM, and b. Contains at least two genomic receptor sites designated as component B and component D, for the integration of at least one ORF encoding at least one aAPX and / or aAM, respectively, and component C is matched to component B, Component C is c. A single ORF encoding at least one aAPX and / or aAM; or d. Is designed to deliver two or more ORFs encoding at least one aAPX and / or aAM, wherein the genome acceptor sites B and D are synthetic constructs designed for recombinase mediated cassette exchange (RMCE).
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