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A universal platform for CAR therapy that targets new antigen indicators of cancer
A universal platform for CAR therapy that targets new antigen indicators of cancer
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机译：针对癌症新抗原指标的CAR治疗通用平台
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摘要
A nucleic acid molecule comprising a nucleotide sequence encoding an inhibitory chimeric antigen receptor (iCAR) capable of preventing or attenuating unwanted activation of an effector immune cell, wherein the iCAR is selected from the group consisting of a mammalian tumor cell , An extracellular domain that specifically binds to a single allelic variant of a polymorphic cell surface epitope that is at least present on all cells of normal mammalian normal tissues; And an intracellular domain comprising at least one signaling component that inhibits effector immune cells. There is further provided a method for the treatment of cancer comprising administering a vector comprising a nucleic acid molecule and a transduced effector immune cell and a transduced effector immune cell.
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