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CHRONIC STRESS-EXPOSED ANIMAL MODEL FOR DIABETES MELLITUS CHARACTERIZED BY OVERPRODUCTION OF NITRIC OXIDE IN BLOOD, VASCULAR ENDOTHELIAL DYSFUNCTION, AND HEAT RATE REDUCTION, METHOD OF PRODUCING SAME, AND USES OF SAME
CHRONIC STRESS-EXPOSED ANIMAL MODEL FOR DIABETES MELLITUS CHARACTERIZED BY OVERPRODUCTION OF NITRIC OXIDE IN BLOOD, VASCULAR ENDOTHELIAL DYSFUNCTION, AND HEAT RATE REDUCTION, METHOD OF PRODUCING SAME, AND USES OF SAME
The present invention relates to a chronic stress-exposed animal model for diabetes mellitus characterized by overproduction of nitric oxide in blood, vascular endothelial dysfunction, and heart rate reduction; a method of producing the same; and uses of the same. More specifically, the present invention relates to a chronic stress-exposed animal model for diabetes mellitus, in which diabetes mellitus can be simply induced physiologically without genetic mutations, and phenotypes thereof are expressed as overproduction of nitric oxide in blood, vascular endothelial dysfunction, and heart rate reduction. The animal model for diabetes mellitus according to the present invention shows a plasma glucose concentration similar to an existing model; shows an increase in plasma nitric oxide concentration that is similar to the clinical type-2 diabetic patient; and shows apparent vascular endothelial dysfunction and heart rate reduction, while being able to significantly reduce the time consumed for inducing the aforementioned features. The chronic stress-exposed animal model for diabetes mellitus of the present invention may be useful in the diabetes research, the investigation of mechanisms of nitric oxide overproduction, vascular endothelial dysfunction, and heart rate reduction caused by diabetes mellitus, or the prevention and treatment thereof. Also, the present invention relates to a pharmaceutical composition and a functional health food composition, comprising linalyl acetate as an active ingredient for alleviating or treating the overproduction of plasma nitric oxide, vascular endothelial dysfunction, and heart rate reduction. The compositions according to the present invention, as they have been confirmed to be effective in normalizing abnormally increased plasma nitric oxide and vascular endothelial dysfunction, may be useful as a drug or a functional health food for alleviation or treatment of plasma nitric oxide overproduction, vascular endothelial dysfunction, and heat rate reduction.;COPYRIGHT KIPO 2019
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