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III III III III Recombinant Microorganism Having Enhanced Productivity of Heme Coproporphyrin III and Uroporphyrin III and Method of Producing Heme Coproporphyrin III and Uroporphyrin III Using the same
III III III III Recombinant Microorganism Having Enhanced Productivity of Heme Coproporphyrin III and Uroporphyrin III and Method of Producing Heme Coproporphyrin III and Uroporphyrin III Using the same
The present invention relates to a recombinant microorganism having improved productivity of heme, coproporphyrin III (Copro III), and uroporphyrin III (Uro III) and a production method for heme, coproporphyrin III, and uroporphyrin III using the same. The recombinant microorganism can cost effectively produce porphyrin group structures at high yield when the recombinant microorganism applied with a gene coating diphtheria toxin Repressor (DtxR) which is a transcription factor capable of leading revelation of the gene related to a heme metabolic pathway, glutamate-1-semialdehyde aminotransferase (HemL), and glutamyl-tRNA reductase (HemA) is used.
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