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PROBING MECHANICAL PROPERTIES OF BIOLOGICAL MATTER

机译：生物物质的力学性能探究

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摘要

A method for probing mechanical properties of cellular bodies is described wherein the method includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particles being attached to a cellular body and each cellular body being positioned on a surface of the holding space; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles in a direction away from the surface of the holding space or in a direction towards the surface of the holding space, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; and, for at least part of the particles attached to the cellular bodies, measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with at least one mechanical property of the cellular body attached to the particle.
机译：描述了一种探测细胞体机械性能的方法，其中该方法包括：在包含在样品架的保持空间中的流体介质中提供多个颗粒，所述多个颗粒中的每一个均附接到细胞体上并且每个细胞主体位于容纳空间的表面上;在所述容纳空间中产生共振体声波，所述共振体声波在远离所述容纳空间的表面的方向上或朝向所述容纳空间的表面的方向上对所述多个粒子施加声力，多个颗粒中的每一个都具有声学对比因子和尺寸，所述声学对比因子和尺寸被选择为使得施加在颗粒上的力大于施加在附着有该颗粒的细胞体上的力。对于附着在细胞体上的至少一部分颗粒，响应于在颗粒上施加的力来测量颗粒的位移，所测得的位移与附着在细胞体上的细胞体的至少一种机械性能有关。粒子。

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