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ANTISENSE ANTIBIOTICS AND BACTERIAL SECRETION BASED DELIVERY SYSTEM TO ELIMINATE DRUG-RESISTANT BACTERIA

机译:基于抗细菌和细菌分泌的递送系统消除抗药性细菌

摘要

The present inventions relates to systems, methods and compositions for the rational design of a new classes of antibiotics targeting non-traditional pathways and genes including metabolism, cell signaling, and stress response using sequence-specific peptide nucleic acids (PNAs). The invention further includes systems, methods and compositions for the efficient delivery of PNAs to intracellular pathogens through a novel use of the bacterial secretion system in combination with a cell lysis switch.
机译:本发明涉及利用序列特异性肽核酸(PNA)合理设计针对非传统途径和基因的新型抗生素的系统,方法和组合物,所述非传统途径和基因包括代谢,细胞信号传导和应激反应。本发明进一步包括通过新颖地使用细菌分泌系统结合细胞裂解开关有效地将PNA递送至细胞内病原体的系统,方法和组合物。

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