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OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF
OXIDIZED BIS(3-INDOLYL)METHANES AND USES THEREOF
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机译：氧化的双（3-吲哚基）甲烷及其用途
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摘要
Disclosed herein are compounds capable of inducing apoptosis through promoting Nur77 interaction with Bcl-2 and through modulating mitochondrial activities. Also disclosed herein are compositions and methods using these compounds and compositions. Nur77 is a key regulator of Bcl-2 activities and is capable of converting Bcl-2 from an anti-apoptotic protein to a pro-apoptotic protein. Small molecules that directly modulate the Nur77/Bcl-2 apoptotic pathways are promising for treating diseases with abnormal levels of Bcl-2, Nur77, or combinations thereof, including cancers.
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