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QUANTUM PLASMONIC RESONANT ENERGY TRANSFER AND ULTRAFAST PHOTONIC PCR

机译:量子等离子体共振能量转移和超快光子PCR

摘要

A rapid and precision molecular diagnostic chip making use of quantum plasmonic resonance energy transfer is disclosed for performing ultrafast polymerase chain reaction (PCR). The chip includes functionally graded microfluidic structures capable of receiving and conveying a sample using self-powered capillary pumping and capable of performing on-chip separation and target pathogen lysis. The chip can include optical traps to selectively trap and enrich various constituents of the sample, such as cell-free deoxyribonucleic acids (cfDNAs) and exosomes. In some cases, a processing device can receive a diagnostic chip, induce PCR within the diagnostic chip, and optionally detect diagnostic data from the samples within the diagnostic chip.
机译:公开了利用量子等离振子共振能量转移的快速和精确的分子诊断芯片,用于进行超快聚合酶链反应(PCR)。该芯片包括功能分级的微流体结构,该结构能够使用自供电的毛细管泵来接收和输送样品,并能够执行芯片上分离和目标病原体裂解。该芯片可以包括光阱,以选择性地捕获和富集样品的各种成分,例如无细胞的脱氧核糖核酸(cfDNA)和外泌体。在某些情况下,处理设备可以接收诊断芯片,在诊断芯片内诱导PCR,并可选地从诊断芯片内的样品中检测诊断数据。

著录项

  • 公开/公告号WO2019086955A3

    专利类型

  • 公开/公告日2019-08-29

    原文格式PDF

  • 申请/专利权人 NATIONAL UNIVERSITY OF SINGAPORE;

    申请/专利号WO2018IB01363

  • 发明设计人 LEE LUKE P.;

    申请日2018-10-31

  • 分类号B01L3;

  • 国家 WO

  • 入库时间 2022-08-21 11:54:53

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