首页> 外国专利> BIOSENSOR DETECTING GLUCOSE LEVELS OF FREE GLUCOSE, HEMOGLOBIN A1C AND GLYCATED BLOOD PROTEINS IN A SINGLE BLOOD SAMPLE

BIOSENSOR DETECTING GLUCOSE LEVELS OF FREE GLUCOSE, HEMOGLOBIN A1C AND GLYCATED BLOOD PROTEINS IN A SINGLE BLOOD SAMPLE

机译:用生物传感器检测单个血液样品中游离葡萄糖,血红蛋白A1C和糖化血液蛋白的葡萄糖水平

摘要

A biosensor for detecting a glucose level of free glucose, hemoglobin Ale (HbAlc), and glycated blood protein from a single blood sample is disclosed, which includes: a first biosensor for detecting a glucose level of the free glucose, a second biosensor for detecting a glucose level of the HbAlc, a third biosensor for detecting a glucose level of the glycated blood proteins; a fourth biosensor for detecting a hemoglobin level; and a fifth biosensor for detecting non- glycated blood proteins level, where the free glucose, the hemoglobin, the HbAlc, the glycated blood proteins and the non-glycated blood proteins are derived from the single blood sample, where each of the first, second, third and fourth biosensor respectively includes a substrate having a first non-fluorescent dye capable of being converted into a first fluorescent dye by a reaction with the first non-fluorescent dye and H2O2, and where the fifth biosensor includes a substrate having a second non-fluorescent dye capable of being converted into a second fluorescent dye by a reaction with the second non-fluorescent dye and a primary amine in the non-glycated blood proteins.
机译:公开了一种用于检测来自单个血样的游离葡萄糖,血红蛋白Ale(HbAlc)和糖化血液蛋白的葡萄糖水平的生物传感器,其包括:用于检测所述游离葡萄糖的葡萄糖水平的第一生物传感器,用于检测游离葡萄糖的葡萄糖的第二生物传感器。 HbAlc的葡萄糖水平,用于检测糖化血液蛋白的葡萄糖水平的第三生物传感器;第四生物传感器,用于检测血红蛋白水平;第五种用于检测非糖化血液蛋白水平的生物传感器,其中游离葡萄糖,血红蛋白,HbAlc,糖化血蛋白和非糖化血液蛋白均来自单一血样,其中第一,第二,第三和第四生物传感器分别包括具有第一非荧光染料的基底,该基底能够通过与第一非荧光染料和H2O2的反应转化为第一荧光染料,其中第五生物传感器包括具有第二非荧光染料的基底-荧光染料,其可以通过与第二非荧光染料和非糖基化血液蛋白中的伯胺反应而转化为第二荧光染料。

著录项

  • 公开/公告号WO2019075471A2

    专利类型

  • 公开/公告日2019-04-18

    原文格式PDF

  • 申请/专利权人 LEE JI HOON;

    申请/专利号WO2018US55904

  • 发明设计人 LEE JI HOON;

    申请日2018-10-15

  • 分类号C12Q1;

  • 国家 WO

  • 入库时间 2022-08-21 11:55:11

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