首页> 外国专利> METHOD FOR PRODUCING CELL POPULATION IN WHICH PERIODONTAL LIGAMENT STEM CELLS ARE CONCENTRATED

METHOD FOR PRODUCING CELL POPULATION IN WHICH PERIODONTAL LIGAMENT STEM CELLS ARE CONCENTRATED

机译:浓缩牙周膜干细胞的细胞群体的方法

摘要

[Problem] The purpose of the present invention is to provide a method for preparing a cell population containing numerous periodontal ligament stem cells, particularly epithelial stem cells from the periodontal ligament and/or periodontal mesenchymal stem cells from the periodontal ligament. [Solution] Provided is a method for producing a cell population in which periodontal ligament stem cells are concentrated, said method including a stem cell selection step in which a cell population that has been isolated from periodontal ligament is cultivated in a culture medium containing a prescribed proliferation factor. Further provided are: a cell population in which periodontal ligament stem cells are concentrated; a pharmaceutical composition having said cell population or the culture supernatant thereof as an active ingredient; a method for producing a dental implant or tooth having a periodontal ligament coating formed using the cell population; and a novel marker for periodontal ligament stem cells.
机译:[问题]本发明的目的是提供一种制备包含大量牙周膜干细胞,特别是来自牙周膜的上皮干细胞和/或来自牙周膜的牙周间充质干细胞的细胞群的方法。 [解决方案]提供了一种浓缩牙周膜干细胞的细胞群的制造方法,该方法包括干细胞选择步骤,其中,从含有牙周膜的细胞中分离出的细胞群在含有规定量的培养基中培养。增殖因子。还提供了:其中牙周膜干细胞浓缩的细胞群;具有所述细胞群或其培养上清液作为活性成分的药物组合物;一种生产具有使用细胞群形成的牙周膜涂层的牙齿植入物或牙齿的方法;和牙周膜干细胞的新标记。

著录项

  • 公开/公告号WO2019074046A1

    专利类型

  • 公开/公告日2019-04-18

    原文格式PDF

  • 申请/专利号WO2018JP37900

  • 发明设计人 OKUBO NAOTO;

    申请日2018-10-11

  • 分类号C12N5/074;A61K35/32;A61L27/38;A61P1/02;C07K14/705;C07K14/485;C07K14/50;C12N15/09;

  • 国家 WO

  • 入库时间 2022-08-21 11:55:12

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