首页> 外国专利> LUTEINIZING HORMONE RECEPTOR BINDING AGENTS AND LUTEINIZING HORMONE AGONISTS TO IDENTIFY, EXPAND, ABLATE AND MODIFY STEM CELLS

LUTEINIZING HORMONE RECEPTOR BINDING AGENTS AND LUTEINIZING HORMONE AGONISTS TO IDENTIFY, EXPAND, ABLATE AND MODIFY STEM CELLS

机译：黄体激素受体结合剂和黄体激素激动剂鉴定，扩增，切除和修饰干细胞

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摘要

The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.

机译：描述了使用促黄体激素受体（LHR）结合剂和促黄体激素（LH）激动剂来富集原始造血干细胞（pHSC）群体，靶向pHSC进行消融和/或扩大pHSC群体。该方法可用于制备治疗性造血干细胞（HSC）群体，为患者准备治疗性HSC移植和/或治疗恶性肿瘤，例如与过度增殖性HSC相关的恶性肿瘤。

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公开/公告号WO2019070740A3

专利类型
公开/公告日2019-05-09

原文格式PDF
申请/专利权人 FRED HUTCHINSON CANCER RESEARCH CENTER;MEMORIAL SLOAN-KETTERING CANCER CENTER;
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申请/专利号WO2018US54004
发明设计人 DUDAKOV JARROD;KIEM HANS-PETER;RADTKE STEPHAN;VAN DEN BRINK MARCEL;VELARDI ENRICO;JAMES SCOTT;
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申请日2018-10-02
分类号A61K35/28;A61K35/51;A61K38/09;A61K38/24;C12N5/10;C12N5/16;C12N5/22;C12N15/63;G01N33/50;
国家 WO
入库时间 2022-08-21 11:55:12

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