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Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors

机译:靶向递送烟酰胺腺嘌呤二核苷酸挽救途径抑制剂

摘要

Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.
机译:公开了化合物和组合物,其中NAMPT药物单元通过在目标作用部位释放NAMPT抑制剂化合物或其衍生物的单元与靶向配体单元连接。还公开了使用本发明的化合物和组合物治疗以靶向的异常细胞为特征的疾病的方法,例如癌症或自身免疫疾病。

著录项

  • 公开/公告号AU2017345262A1

    专利类型

  • 公开/公告日2019-06-06

    原文格式PDF

  • 申请/专利权人 SEATTLE GENETICS INC.;

    申请/专利号AU20170345262

  • 发明设计人 NEUMANN CHRISTOPHER SCOTT;OLIVAS KATHLEEN;

    申请日2017-10-18

  • 分类号A61K47/68;

  • 国家 AU

  • 入库时间 2022-08-21 11:56:15

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