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CONSTRUCTION METHOD FOR APPLICABILITY EVALUATION MODEL OF IMMUNE STATE OF T LYMPHOCYTE OF HEPATIC DISEASES OF HEPATITIS B
CONSTRUCTION METHOD FOR APPLICABILITY EVALUATION MODEL OF IMMUNE STATE OF T LYMPHOCYTE OF HEPATIC DISEASES OF HEPATITIS B
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机译:乙型肝炎肝病患者T淋巴细胞免疫状态适用性评价模型的构建方法
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摘要
Provided are a construction method for an applicability evaluation model of an immune state of T lymphocyte of hepatic diseases of hepatitis B, comprising: (1) detecting T cell activator factors and inhibitory/exhaustion molecules of peripheral blood of a patient by means of a flow cytometry so as to obtain levels of all T cell factors of each detection sample; (2) collecting population statistics, virology, liver function and liver hardness value data of each case and carrying out correlation analysis on clinical indexes and a T cell immunity evaluation index to find the clinical indexes having a close correlation; (3) utilizing the different clinical indexes to establish a plurality of scored ROC curve models, comparing areas under the ROC curve, flexibilities and specificities of different models and selecting the optimal ROC curve; and (4) obtaining different immuno-clinic score equations according to the optimal ROC curve so as to further optimize the optimal immuno-clinic score equation used for evaluating the overall immune state of the T cell.
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