首页> 外国专利> CONSTRUCTION METHOD FOR APPLICABILITY EVALUATION MODEL OF IMMUNE STATE OF T LYMPHOCYTE OF HEPATIC DISEASES OF HEPATITIS B

CONSTRUCTION METHOD FOR APPLICABILITY EVALUATION MODEL OF IMMUNE STATE OF T LYMPHOCYTE OF HEPATIC DISEASES OF HEPATITIS B

机译:乙型肝炎肝病患者T淋巴细胞免疫状态适用性评价模型的构建方法

摘要

Provided are a construction method for an applicability evaluation model of an immune state of T lymphocyte of hepatic diseases of hepatitis B, comprising: (1) detecting T cell activator factors and inhibitory/exhaustion molecules of peripheral blood of a patient by means of a flow cytometry so as to obtain levels of all T cell factors of each detection sample; (2) collecting population statistics, virology, liver function and liver hardness value data of each case and carrying out correlation analysis on clinical indexes and a T cell immunity evaluation index to find the clinical indexes having a close correlation; (3) utilizing the different clinical indexes to establish a plurality of scored ROC curve models, comparing areas under the ROC curve, flexibilities and specificities of different models and selecting the optimal ROC curve; and (4) obtaining different immuno-clinic score equations according to the optimal ROC curve so as to further optimize the optimal immuno-clinic score equation used for evaluating the overall immune state of the T cell.
机译:提供一种乙型肝炎肝病T淋巴细胞免疫状态适用性评价模型的构建方法,其包括:(1)通过流检测患者外周血的T细胞活化因子和抑制/耗竭分子。细胞计数法以获得每个检测样品中所有T细胞因子的水平; (2)收集每例病例的人口统计资料,病毒学,肝功能和肝硬度值数据,对临床指标和T细胞免疫评价指标进行相关分析,找出密切相关的临床指标; (3)利用不同的临床指标建立多个得分ROC曲线模型,比较ROC曲线下面积,不同模型的灵活性和特异性,选择最佳的ROC曲线; (4)根据最佳ROC曲线获得不同的免疫-临床评分方程,以进一步优化用于评估T细胞总体免疫状态的最佳免疫-临床评分方程。

著录项

  • 公开/公告号WO2019033444A1

    专利类型

  • 公开/公告日2019-02-21

    原文格式PDF

  • 申请/专利权人 HUANG YUEHUA;PRESEE BIOTECHNOLOGY CO. LTD.;

    申请/专利号WO2017CN98402

  • 发明设计人 ZENG SHOUJIE;

    申请日2017-08-22

  • 分类号G06F19;

  • 国家 WO

  • 入库时间 2022-08-21 11:56:35

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