首页> 外国专利> COMPOSITIONS FOR USE AS A PROPHYLACTIC AGENT TO THOSE AT RISK OF INFECTION OF TUBERCULOSIS, OR AS SECONDARY AGENTS FOR TREATING INFECTED TUBERCULOSIS PATIENTS

COMPOSITIONS FOR USE AS A PROPHYLACTIC AGENT TO THOSE AT RISK OF INFECTION OF TUBERCULOSIS, OR AS SECONDARY AGENTS FOR TREATING INFECTED TUBERCULOSIS PATIENTS

机译:用作感染结核病风险的预防性药物的组合物,或用作治疗感染结核病患者的辅助制剂的组合物

摘要

The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberculosis complex, preferably a M. tuberculosis clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM- phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberculosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.
机译:本发明涉及由属于结核分枝杆菌复合物的分离的微生物,优选结核分枝杆菌临床分离株,更优选结核分枝杆菌临床分离株组成的冷冻干燥的组合物,其特征在于通过灭活其包含PhoP表型通过遗传删除Rv0757基因和删除第二个基因Rv2930(fadD26),可防止PDIM产生(PDIM表型)(MTBVAC菌株),以及蔗糖和谷氨酸钠作为稳定剂或赋形剂。本发明还涉及通过向冷冻干燥的组合物中加入水,优选注射用无菌水而获得的重构组合物及其用途,特别是用作对有结核分枝杆菌感染风险的人的预防剂。或有患结核病风险的人,或作为治疗感染结核病患者的辅助药物。

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