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ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED CANCER THERAPY
ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED CANCER THERAPY
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机译：抗VEGFR2人类抗体用于抗血管生成和靶向治疗
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摘要
An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.
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机译：公开了一种分离的抗体或其抗原结合片段，其对位于人血管内皮生长因子受体2的域1或域3（VEGFR2; SEQ ID NO：74）中的表位具有特异性结合亲和力。 VEGFR2的结构域3内的表位位于SEQ ID NO：74的氨基酸残基250和270之间。抗体或其抗原结合片段在制备用于抑制肿瘤生长，肿瘤血管生成和还公开了/或在有此需要的受试者中诱导癌细胞的细胞毒性。还公开了一种检测生物学样品中的肿瘤血管内皮细胞或癌细胞中VEGFR2的存在的方法。
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