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首页> 外国专利> PROTOFIBRIL-BINDING ANTIBODIES AND THEIR USE IN THERAPEUTIC AND DIAGNOSTIC METHODS FOR PARKINSON'S DISEASE, DEMENTIA WITH LEWY BODIES AND OTHER ALPHA-SYNUCLEINOPATHIES

PROTOFIBRIL-BINDING ANTIBODIES AND THEIR USE IN THERAPEUTIC AND DIAGNOSTIC METHODS FOR PARKINSON'S DISEASE, DEMENTIA WITH LEWY BODIES AND OTHER ALPHA-SYNUCLEINOPATHIES

机译：结合原纤维的抗体及其在帕金森氏病，伴有小体的痴呆和其他阿尔法突触核蛋白病的治疗和诊断方法中的用途

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Antibodies and fragments thereof have high affinity for human a-synuclein protofibrils and low binding of a-synuclein monomers, wherein the antibodies or fragments have specified Complementarity Determining Region (CDR) sequences. Compositions comprise such an antibody or fragment and methods of detecting a-synuclein protofibrils use such an antibody or fragment. In further embodiments, methods of preventing, delaying onset of or treating a neurodegenerative disorder with a-synuclein pathology comprise administering such an antibody or fragment, and such an antibody or fragment is used in the manufacture of a pharmaceutical composition for treatment of a neurodegenerative disorder with a-synuclein pathology. Such an antibody or fragment is used in the diagnosis or monitoring of the development of a neurodegenerative disorder with a-synuclein pathology, and in methods for reducing or inhibiting a-synuclein aggregation by administration of such an antibody or fragment.
机译：抗体及其片段对人α-突触核蛋白原纤维具有高亲和力，而α-突触核蛋白单体的结合性低，其中抗体或片段具有特定的互补决定区（CDR）序列。组合物包含这样的抗体或片段，并且检测α-突触核蛋白原纤维的方法使用这样的抗体或片段。在进一步的实施方案中，用α-突触核蛋白病理学预防，延迟神经退行性疾病的发作或治疗神经退行性疾病的方法包括施用此类抗体或片段，并且该抗体或片段用于制备用于治疗神经退行性疾病的药物组合物。与α-突触核蛋白的病理学有关。此类抗体或片段用于诊断或监测具有α-突触核蛋白病理学的神经退行性疾病的发展，以及用于通过施用此类抗体或片段减少或抑制α-突触核蛋白聚集的方法。

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