首页> 外国专利> PROCEDURE FOR PREPARING METHYL ESTER OF ACID 3 - (3S) -7-BROMO-2-OXO-5- (PYRIDIN-2-IL) -2,3-DIHYDRO-1H- 1,4 -BENZODIAZEPIN-3- IL PROPIONIC, AND USEFUL COMPOUNDS IN THAT PROCEDURE (Machine-translation by Google Translate, not legally binding)

PROCEDURE FOR PREPARING METHYL ESTER OF ACID 3 - (3S) -7-BROMO-2-OXO-5- (PYRIDIN-2-IL) -2,3-DIHYDRO-1H- 1,4 -BENZODIAZEPIN-3- IL PROPIONIC, AND USEFUL COMPOUNDS IN THAT PROCEDURE (Machine-translation by Google Translate, not legally binding)

机译：制备丙烯酸3-（（3S）-7-BROMO-2-OXO-5-（PYRIDIN-2-IL）-2,3-DIHYDRO-1H- [1,4] -BENZODIAZEPIN-3-的甲基酯的方法IL]在该程序中具有比例和有用的化合物（由Google翻译进行机器翻译，不具有法律约束力）

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摘要

Procedure for preparing 3 - [(3S) -7-bromo-2-oxo-5- (pyridin-2-yl) -2,3-dihydro-1H- [1,4] -benzodiazepin-3-methyl ester il] propionic, and compounds useful in that procedure. The present invention relates to a process for preparing 3 - [(3S) -7-bromo-2-oxo-5- (pyridin-2-yl) -2,3-dihydro-1H- [1] methyl ester. 4] -benzodiazepin-3-yl] propionic starting from (2-amino-5-bromo-phenyl) -pyridin-2-yl-methanone. Also, the present invention relates to new compounds useful as intermediates in that process, the salt of (4S) -4-amino-5- [4-bromo-2- (pyridine-2-carbonyl) anilino] -hydrochloride. methyl oxo-pentanoate and methyl (4S) -4- (benzyloxycarbonylamino) -5- [4-bromo-2- (pyridin-2-carbonyl) anilino] -5-oxo-pentanoate. (Machine-translation by Google Translate, not legally binding)

机译：制备3-[（3S）-7-溴-2-氧-5-（吡啶-2-基）-2,3-二氢-1H- [1,4]-苯并二氮杂-3-甲基酯il]的方法丙酸和可用于该程序的化合物。本发明涉及制备3-[（3S）-7-溴-2-氧代-5-（吡啶-2-基）-2，3-二氢-1H- [1]甲酯的方法。 4]-苯并二氮杂-3-基]丙酸从（2-氨基-5-溴-苯基）吡啶-2-基-甲酮开始。同样，本发明涉及在该方法中用作中间体的新化合物，即（4S）-4-氨基-5- [4-溴-2-（吡啶-2-羰基）苯胺基]-盐酸盐。氧代戊酸甲酯和（4S）-4-（苄氧羰基氨基）-5- [4-溴-2-（吡啶-2-羰基）苯胺基] -5-氧代戊酸甲酯。（通过Google翻译进行机器翻译，没有法律约束力）

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公开/公告号ES2697918A1

专利类型
公开/公告日2019-01-29

原文格式PDF
申请/专利权人 MOEHS IBERICA S.L.;
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申请/专利号ES20170030986
发明设计人 SANCHEZ CASALS CARLES;DOBARRO RODRIGUEZ ALICIA;
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申请日2017-07-28
分类号C07D401/04;C07D213/50;C07D243/24;C07D487/04;
国家 ES
入库时间 2022-08-21 11:59:30

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