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TLR 4 and 9 receptor agonists to prevent septic complications of post-traumatic immunosuppression in patients hospitalized for severe traumas
TLR 4 and 9 receptor agonists to prevent septic complications of post-traumatic immunosuppression in patients hospitalized for severe traumas
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机译:TLR 4和9受体激动剂可预防严重创伤住院患者的创伤后免疫抑制引起的败血症并发症
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摘要
The present invention concerns a pharmaceutical composition comprising at least one agonist of at least one Toll Like receptor (TLR) chosen from TLR 4 and 9, for use in the prophylactic treatment of septic complications of post-traumatic systemic immunodepression in a patient who has suffered one or more severe traumatic injuries and is hospitalized in particular in an intensive care unit. Preferably, said TLR 4 agonist is monophosphoryl lipid A (MPLA) or deacylated 3-O-monophosphoryl lipid A (3D-MPLA) and said TLR 9 agonist is a CpG oligodeoxynucleotide (CpG ODN).
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