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Fusion Protein with polipÉptido extension of average life
Fusion Protein with polipÉptido extension of average life
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机译：融合蛋白具有延长平均寿命的polipÉptido
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摘要
It provides a fusion protein.(i) comprising a Biologically Active polypeptide; and (ii) a rest polipeptídico extension that includes Half Life 2 - 80 units regardless of the selected sequences of amiNoácidos according to SEC ID no: 1 X1 x2 X3: - - - - - X4 X5 X6, x8 X9 D - - - - - (x10, X11 SEC ID no: 1), in whichRegardless: x1 is P or is absent; x2 is v or is absent; X3 is P or t is P; x4 or X5 is t or t; D V; X6 is G or t is, x8, X9 is q or s; e, G or K; X10 is a, and P or t; and X11 is a, p or t.The Rest polipeptídico extension of the average life has Unfolded conformation and generally provides a fusion protein with a large hydrodynamic RADIUS which can prevent the re clearanceNal. As a result, increases the Biological half-life of the fusion protein, and thus can Prolong the Biological effect of biologically active polypeptide.
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