首页> 外国专利> An agent increasing effectiveness of DNA vaccine directed against a virus, DNA plasmid preparation, DNA vaccine, method for obtaining modified expressive vector and the application of nucleotide sequence recognized by the agent NF kappa B.

An agent increasing effectiveness of DNA vaccine directed against a virus, DNA plasmid preparation, DNA vaccine, method for obtaining modified expressive vector and the application of nucleotide sequence recognized by the agent NF kappa B.

机译：一种针对病毒的DNA疫苗的增效剂，DNA质粒制备，DNA疫苗，获得修饰的表达载体的方法以及由NF kappa B识别的核苷酸序列的应用。

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摘要

The invention is related to a factor increasing efficiency of a DNA vaccine aimed against a virus, a plasmid DNA preparation, a DNA vaccine, a method of obtaining a modified 3NFKB expression vector and use of a nucleotide sequence recognised by NFKB. More particularly, the provided solution is related to use of a DNA sequence recognised by the NF kappa B nuclear transcription factor (NFKB,nuclear factor kappa B) in a vaccine in order to ensure effective vaccine plasmid transport into the nucleus and to enhance transcription levels of the introduced gene-coding a selected antigen.

机译：本发明涉及针对病毒的DNA疫苗的效率提高因子，质粒DNA制备物，DNA疫苗，获得修饰的3NFKB表达载体的方法以及由NFKB识别的核苷酸序列的使用。更具体地，所提供的解决方案涉及在疫苗中使用被NFκB核转录因子（NFKB，核因子κB）识别的DNA序列，以确保有效的疫苗质粒转运到核中并增强转录水平。编码选定抗原的导入基因的表达。

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公开/公告号PL231230B1

专利类型
公开/公告日2019-02-28

原文格式PDF
申请/专利权人 INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK;
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申请/专利号PL20150411543
发明设计人 SIRKO AGNIESZKA;GÓRA-SOCHACKA ANNA;ZAGÓRSKI-OSTOJA WŁODZIMIERZ;STACHYRA ANNA;REDKIEWICZ PATRYCJA;MIDOUX PATRICK;PICHON CHANTAL;
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申请日2015-03-11
分类号A61K39;A61K39/12;A61P31/16;
国家 PL
入库时间 2022-08-21 12:01:19

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