首页> 外国专利> COMPOUNDS AND METHODS FOR INHIBITING ADIPOGENESIS BY INHIBITING THE GENE FAM129B AND/OR PROTEIN FAM129B EXPRESSION.

COMPOUNDS AND METHODS FOR INHIBITING ADIPOGENESIS BY INHIBITING THE GENE FAM129B AND/OR PROTEIN FAM129B EXPRESSION.

机译：通过抑制基因FAM129B和/或蛋白质FAM129B的表达来抑制脂肪形成的化合物和方法。

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摘要

The present invention describes compounds, compositions, methods and the uses thereof intended to reduce the capacity of adipocytes and further cells of the organisms to produce and store lipid molecules; also reduces the number of cells induced to the fat differentiation, thus reducing the number of cells that produce and store lipids and the synthesis of lipids in differentiated cells. The present invention is related to compounds, compositions, methods and uses thereof for inhibiting the expression of the gene fam129b or regulating the function of the protein Fam129B, modulating therefore the activity of the genes paparg2, cebpa and srebf1, which together coordinate the expression of the adipose phenotype and the synthesis of triglycerides.

机译：本发明描述了旨在降低生物的脂肪细胞和其他细胞产生和储存脂质分子的能力的化合物，组合物，方法及其用途。还减少了诱导脂肪分化的细胞数量，从而减少了在分化细胞中产生和储存脂质以及脂质合成的细胞数量。本发明涉及化合物，组合物，方法及其用途，其用于抑制基因fam129b的表达或调节蛋白Fam129B的功能，从而调节基因paparg2，cebpa和srebf1的活性，它们共同协调了pamarg2，cebpa和srebf1的表达。脂肪表型和甘油三酸酯的合成。

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公开/公告号MX365182B

专利类型
公开/公告日2019-05-21

原文格式PDF
申请/专利权人 CENTRO DE INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL I.P.N.;
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申请/专利号MX20120003056
发明设计人 JORGE TONATIUH AYALA SUMUANO;WALID KURI HARCUCH;MEYTHA MARSCH MORENO;CRISTINA VÉLEZ DEL VALLE;ALICIA BELTRÁN LANGARICA;
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申请日2012-03-13
分类号A61K31/713;C12N15/113;
国家 MX
入库时间 2022-08-21 12:01:39

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