首页> 外国专利> APPLICATION OF ADAMTS13 FOR TREATMENT, REDUCING THE INTENSITY AND / OR PREVENTION OF A VASA-OCCLUSIVE CRISIS WITH Sickle-cell anemia, ACUTE DAMAGE TO LIGHT AND / OR ACUTE RESPIRATOR-DYNESIS

APPLICATION OF ADAMTS13 FOR TREATMENT, REDUCING THE INTENSITY AND / OR PREVENTION OF A VASA-OCCLUSIVE CRISIS WITH Sickle-cell anemia, ACUTE DAMAGE TO LIGHT AND / OR ACUTE RESPIRATOR-DYNESIS

机译:ADAMTS13在治疗,降低镰刀状细胞性贫血,急性损伤轻度和/或急性呼吸道呼吸机病的VASA闭塞性危机中的应用,以减轻和/或预防VASA闭塞性危机

摘要

The present disclosure relates to compositions and a method for treating, reducing the intensity or preventing vaso-occlusive crisis (VOC) in a subject suffering from sickle cell anemia (SCD). The present disclosure also relates to compositions and methods for treating, reducing the intensity or preventing lung damage in a subject suffering from acute lung injury (ALI) and / or acute respiratory distress syndrome (ARDS) or at risk of developing them. The present disclosure relates to a disintegrin and metalloproteinase with a thrombospondin type 1 motif 13 (A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member-13-ADAMTS13) or a composition containing ADAMTS13 for the treatment, reduction of intensity and / or prevention of VOC or for treating, reducing the intensity and / or preventing lung damage in a subject suffering from ALI and / or ARDS or at risk of developing.
机译:本公开涉及用于治疗,降低镰状细胞性贫血(SCD)的受试者的强度,或预防血管闭塞性危机(VOC)的组合物和方法。本公开还涉及用于在患有急性肺损伤(ALI)和/或急性呼吸窘迫综合征(ARDS)或有发展它们的风险的受试者中治疗,降低强度或预防肺损伤的组合物和方法。本公开涉及具有血小板反应蛋白1型基序13的解整合素和金属蛋白酶(具有血小板反应蛋白1型基序的解整合素和金属蛋白酶,成员-13-ADAMTS13)或包含ADAMTS13的组合物,用于治疗,降低强度和/或预防VOC或用于治疗,减轻ALI和/或ARDS或有发展风险的受试者的强度和/或预防肺损伤。

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