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LAGLIDADG HOMING ENDONUCLEASE DIVERSE T-CELL RECEPTOR ALPHA GENET AND APPLICATIONS THEREOF

机译:LAGLIDADG归巢核酸酶多种T细胞受体α基因组及其应用

摘要

Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the -Onul subfamily of LHEs. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefore are also provided.
机译:本文公开了用于使人TCR-α基因失活的组合物,其包含工程化的LAGLIDADG归巢内切核酸酶(LHE)及其衍生物,特别是衍生自LHE的Onul亚家族成员。因此,还提供了编码此类核酸内切酶的多核苷酸,包含所述多核苷酸的载体,包含或已经用此类核酸内切酶处理的细胞以及由此衍生的治疗组合物。

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