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COMPOSITIONS COMPREHENSIVE ENZYM-TENDABLE AMPHETAMINE PRODRUGS AND ITS INHIBITORS

机译:全面的酶促安非他明药物组合物及其抑制剂

摘要

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an amphetamine prodrug that provides enzymatically-controlled release of amphetamine or an amphetamine analog. The composition can further comprise an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of amphetamine or the amphetamine analog from the amphetamine prodrug so as to attenuate enzymatic cleavage of the amphetamine prodrug.
机译:提供了药物组合物及其使用方法,其中药物组合物包含苯丙胺前药,其提供酶促控制的苯丙胺或苯丙胺类似物的释放。该组合物可以进一步包含与一种或多种酶相互作用的酶抑制剂,所述酶介导苯丙胺前体药物中苯丙胺或苯丙胺类似物的酶控释放,从而减弱苯丙胺前体药物的酶促裂解。

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