首页> 外国专利> use of a compound, compound, pharmaceutical composition, method for treating a condition or disorder in which t-type calcium channels or voltage regulated sodium channels are involved, compound or a pharmaceutically acceptable salt thereof and use of a compound or a pharmaceutically acceptable salt thereof.

use of a compound, compound, pharmaceutical composition, method for treating a condition or disorder in which t-type calcium channels or voltage regulated sodium channels are involved, compound or a pharmaceutically acceptable salt thereof and use of a compound or a pharmaceutically acceptable salt thereof.

机译：化合物，化合物，药物组合物的用途，用于治疗涉及t型钙通道或电压调节的钠通道的疾病或病症的方法，化合物或其药学上可接受的盐以及化合物或其药学上可接受的盐的用途。

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摘要

The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

机译：本发明涉及式（I）的芳基取代的羧酰胺衍生物或其药学上可接受的盐，其具有T型钙通道或电压门控钠通道的阻断活性，作为对河豚毒素敏感的（TTX-S）阻断剂如NaV1 .3和NaV1.7，可用于治疗或预防涉及T型钙通道或电压门控钠通道的疾病。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗其中涉及T型钙通道或电压门控钠通道的疾病中的用途。

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公开/公告号BRPI1015097A2

专利类型
公开/公告日2019-09-24

原文格式PDF
申请/专利权人 RAQUALIA PHARMA INC.;
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申请/专利号BR2010PI15097
发明设计人 KAORU SHIMADA;MIKIO MORITA;SHUZO WATANABE;TADASHI INOUE;TATSUYA YAMAGISHI;YOSHIMASA ARANO;
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申请日2010-05-31
分类号A61K31/44;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/4706;A61K31/4709;A61K31/4725;A61K31/497;A61K31/506;A61P1;A61P1/18;A61P9;A61P9/06;A61P13;A61P13/10;A61P15;A61P19/02;A61P21/02;A61P25;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/28;A61P29;A61P35;A61P43;C07D213/65;C07D215/40;C07D241/18;C07D401/12;C07D401/14;C07D405/12;C07D409/12;C07D413/12;C07D417/12;
国家 BR
入库时间 2022-08-21 12:03:00

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