首页> 外国专利> 'Multivalent anthelmintic vaccine and method of vaccinating an individual in need of it against hookworm infection and schistosomiasis'

'Multivalent anthelmintic vaccine and method of vaccinating an individual in need of it against hookworm infection and schistosomiasis'

机译：“多价驱虫疫苗和为有钩虫感染和血吸虫病的人接种疫苗的方法”

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摘要

A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are Necator americanus antigens, although antigens from other hookworm species (e.g. Ancylostoma duodenale) may also be employed. The schistosome antigen is preferably a Schistosoma mansoni or a Schistosoma haematobium antigen although antigens from other schistosome species (e.g. Schistosoma japonicum) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {Necator americanus) to produce recombinant chimeric antigens.

机译：一种多价驱虫疫苗同时针对钩虫和血吸虫病。疫苗至少包括重组第三阶段幼虫钩虫抗原，重组成年阶段钩虫抗原和重组血吸虫抗原。尽管还可以使用来自其他钩虫物种的抗原（例如十二指肠蝇），但钩虫抗原优选是美洲轮虫（Necator americanus）抗原。血吸虫抗原优选是曼氏血吸虫或血吸虫血吸虫抗原，尽管也可以使用来自其他血吸虫物种（例如日本血吸虫）的抗原。在某些情况下，可以将血吸虫抗原的全部或部分序列与钩虫（Necator americanus）的全部或部分序列融合，以产生重组嵌合抗原。

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公开/公告号BRPI0910168A2

专利类型
公开/公告日2019-09-24

原文格式PDF
申请/专利权人 THE GEORGE WASHINGTON UNIVERSITY;
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申请/专利号BR2009PI10168
发明设计人 ALEXANDER LOUKAS;AMI SHAH BROWN;BIN ZHAN;DAVID DIEMERT;GADDAM GOUD;JEFFREY BETHONY;MARIA ELENA BOTTAZZO;MARK PEARSON;PETER GIACOMANTONIO;PETER HOTEZ;
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申请日2009-06-30
分类号A61K39/295;A61K39/002;A61P33;A61P33/12;
国家 BR
入库时间 2022-08-21 12:03:02

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