首页> 外国专利> antibody, methods for treating cancer in a human patient, for inhibiting phosphate transport in mammalian cells, for preparing an antibody, for immunizing a mammal, for generating slc34a2 immunoreactive antibodies, and for screening for or identifying agents or compounds that modulate slc34a2, composition isolated nucleic acid unicellular host isolated immunogenic slc34a2 polypeptide and vaccine

antibody, methods for treating cancer in a human patient, for inhibiting phosphate transport in mammalian cells, for preparing an antibody, for immunizing a mammal, for generating slc34a2 immunoreactive antibodies, and for screening for or identifying agents or compounds that modulate slc34a2, composition isolated nucleic acid unicellular host isolated immunogenic slc34a2 polypeptide and vaccine

机译:抗体,用于治疗人类患者的癌症,抑制哺乳动物细胞中磷酸盐转运,制备抗体,免疫哺乳动物,产生slc34a2免疫反应性抗体以及筛选或鉴定调节slc34a2的试剂或化合物的方法,分离的组合物核酸单细胞宿主分离的免疫原性slc34a2多肽和疫苗

摘要

"fully human isolated, humanized, superficially modified or chimerized antibody, uses of an antibody, methods for making an antibody, for generating slc34a2 immunoreactive antibodies, and for screening or identifying slc34a2 modulating agents or compounds, compositions, isolated nucleic acid, host single cell and vaccines. " The present disclosure generally relates to the napi2b membrane transporter (slc34a2) as a target for therapy, including immunotherapy, and for cancer therapy. the slc34a2 epitope peptide including amino acids 312-340 of slc34a2 has been identified as an ovarian cancer epitope using the mx35 monoclonal antibody. The invention also relates to the use of slc34a2 and particularly slc34a2 peptides in the generation of antibodies having anti-tumor or anti-cancer activity or in stimulating an immune response. The invention further relates to antibodies specifically directed against napi2b (slc34a2) and peptide (s) slc34a2 (s), including surface-modified, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treating tumors and cancer are also provided. Assays for screening and identifying compounds directed against slc34a2, including the slc34a2 epitope peptide, and additional antibodies are provided.
机译:“完全人类分离,人源化,表面修饰或嵌合的抗体,抗体的用途,制备抗体的方法,产生slc34a2免疫反应性抗体以及筛选或鉴定slc34a2调节剂或化合物,组合物,分离的核酸,宿主单细胞本公开总体上涉及作为治疗靶标的napi2b膜转运蛋白(slc34a2),包括免疫治疗和癌症治疗。使用mx35单克隆抗体已将包含slc34a2氨基酸312-340的slc34a2表位肽鉴定为卵巢癌表位。本发明还涉及slc34a2尤其是slc34a2肽在具有抗肿瘤或抗癌活性的抗体的产生中或在刺激免疫应答中的用途。本发明进一步涉及特异性针对napi2b(slc34a2)和一种或多种肽slc34a2的抗体,包括表面修饰的,嵌合的,单链和人源化的抗体。还提供了产生免疫应答以及治疗肿瘤和癌症的方法。提供了筛选和鉴定针对slc34a2的化合物(包括slc34a2表位肽)的方法,以及其他抗体。

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