首页> 外国专利> azolcarboxamide or salt compound thereof and use thereof for the treatment of urinary frequency, urinary urgency, urinary incontinence and lower urinary tract pain associated with various lower urinary tract diseases, and various diseases accompanied by pain

azolcarboxamide or salt compound thereof and use thereof for the treatment of urinary frequency, urinary urgency, urinary incontinence and lower urinary tract pain associated with various lower urinary tract diseases, and various diseases accompanied by pain

机译：偶氮羧酰胺或其盐化合物及其在治疗与各种下尿路疾病以及伴随疼痛的各种疾病相关的尿频，尿急，尿失禁和下尿路疼痛中的用途

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摘要

azolcarboxamide compound or salt thereof is an object of the present invention to provide a therapeutic and / or prophylactic agent for urinary frequency, urinary urgency and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by Lower urinary tract pain, such as interstitial cystitis, chronic prostatitis and the like, and various pain-accompanied diseases, based on excellent trka receptor inhibitory action. a new azolcarboxamide compound, wherein a thiazole ring or an oxazole ring is attached to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof , is confirmed to have potent trka receptor inhibitory activity, and is capable of being used as a therapeutic and / or prophylactic agent that is excellent in efficacy and safety for urinary frequency, urinary urgency and urinary incontinence associated with various tract diseases. Lower urinary bladder, including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis and the like, and various pain-accompanied diseases, thereby completing the present invention.

机译：本发明的目的是提供一种偶氮羧酰胺化合物或其盐，其用于治疗和/或预防与多种下尿道疾病有关的尿频，尿急和尿失禁，所述下尿道疾病包括膀胱过度活动症，各种下尿道疾病并伴有下尿道基于优异的trka受体抑制作用，诸如间质性膀胱炎，慢性前列腺炎等之类的道痛以及各种疼痛伴随疾病。已证实其中噻唑环或恶唑环通过羧酰胺连接到苯环，吡啶环，哒嗪环，噻吩环，吡唑环或吡咯环的新的偶氮羧酰胺化合物或其盐，具有有效的trka受体抑制活性，并能够用作治疗和/或预防剂，对与各种疾病相关的尿频，尿急和尿失禁具有出色的疗效和安全性。下膀胱，包括膀胱过度活动症，伴有下尿路疼痛的各种下尿路疾病，例如间质性膀胱炎，慢性前列腺炎等，以及各种疼痛伴随疾病，从而完成了本发明。

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公开/公告号BRPI0818201B1

专利类型
公开/公告日2019-01-29

原文格式PDF
申请/专利权人 ASTELLAS PHARMA INC.;
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申请/专利号BR2008PI18201
发明设计人 AKIRA SUGA;HIDENORI AZAMI;KEIZO SUGASAWA;KENICHI KAWAGUCHI;MASAYUKI TANAHASHI;RYUSHI SEO;SHUNICHIRO MATSUMOTO;TORU WATANABE;TAKAHO NOMURA;TAKASHI SHIN;TOMOAKI ABE;
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申请日2008-10-23
分类号C07D263/34;A61K31/421;A61K31/422;A61K31/426;A61K31/427;A61K31/4439;A61K31/444;A61K31/454;A61K31/4545;A61K31/5377;A61P13/02;A61P43;C07D277/20;C07D277/56;C07D413/12;C07D417/12;C07D417/14;
国家 BR
入库时间 2022-08-21 12:03:06

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