首页> 外国专利> The molecule of connection with neutralizing activity of vu00ecrus of rabies variant of a functional molecule of connection, imunoconjugado, nucleic acid molecule, vector, host, method for producing a molecule of connection or a functional variant, pharmaceutical composition, use d And one molecule of connection, a functional variant, a imunoconjugado as, or a composition, kit.Method for identifying a molecule of connection or a molecule of nucleic acid, and a collection of molecules of human connection in the packet superfu00eccie replicable genetic

The molecule of connection with neutralizing activity of vu00ecrus of rabies variant of a functional molecule of connection, imunoconjugado, nucleic acid molecule, vector, host, method for producing a molecule of connection or a functional variant, pharmaceutical composition, use d And one molecule of connection, a functional variant, a imunoconjugado as, or a composition, kit.Method for identifying a molecule of connection or a molecule of nucleic acid, and a collection of molecules of human connection in the packet superfu00eccie replicable genetic

机译：具有连接功能分子的狂犬病变体v，中和活性的连接分子，免疫缀合体，核酸分子，载体，宿主，产生连接分子或功能变体的方法，药物组合物，用途和连接分子，功能变体，免疫偶联物或组合物，试剂盒。在可复制基因组中鉴定连接分子或核酸分子以及人类连接分子集合的方法

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The molecule of connection with neutralizing activity of vu00ecrus of rabies variant of a functional molecule of connection, imunoconjugado, nucleic acid molecule, vector, host, method for producing a molecule of connection or a functional variant, pharmaceutical composition, use of A molecule of connection, a functional variant, a imunoconjugado as, or a composition, kit.Method for identifying a molecule of connection or a molecule of nucleic acid, and a collection of molecules of human connection in superfu00eccie genetic packages are replicable. The present invention provides binding molecules that specifically bind to rabies virus and are able to neutralize the virus.The invention further provides nucleic acid molecules that encode the molecules of connection, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The molecules of connection can be used in the diagnosis, prophylaxis and / or Treatment of a condition that is the result of the rabies virus.Preferably, they can be used in prophylaxis of post exposure rabies.

机译：具有连接功能分子狂犬病变体v，中和活性的连接分子，免疫缀合体，核酸分子，载体，宿主，连接分子或功能变体的产生方法，药物组合物，A分子的用途可以复制表面遗传学包装中用于鉴定连接分子或核酸分子的方法以及人类连接分子的集合的方法，包括功能变体，免疫偶联物或组合物试剂盒。本发明提供了特异性结合狂犬病毒并且能够中和该病毒的结合分子。本发明进一步提供了编码连接分子的核酸分子，包含该结合分子的组合物以及鉴定或产生该结合分子的方法。连接分子可用于狂犬病毒结果的诊断，预防和/或治疗。优选地，它们可用于预防暴露后狂犬病。

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公开/公告号BRPI0511479B8

专利类型
公开/公告日2019-01-15

原文格式PDF
申请/专利权人 CRUCELL HOLLAND B.V.;CRUCELL HOLLAND BV;JANSSEN VACCINES & PREVENTION B.V.;JANSSEN VACCINES & PREVENTION BV;
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申请/专利号BR2005PI11479
发明设计人 ROBERT ARJEN KRAMER;WILLEM EGBERT MARISSEN;ALEXANDER BERTHOLD HENDRIK BAKKER;CORNELIS ADRIAAN DE KRUIF;
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申请日2005-05-26
分类号A61K39/395;A61P31/14;C07K16/10;C12N5/10;C12N15/13;C12N15/63;G01N33/569;
国家 BR
入库时间 2022-08-21 12:03:11

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