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A method for confirming the detection and enumeration of suspected target cells in a blood sample comprising a mixed cell population.
A method for confirming the detection and enumeration of suspected target cells in a blood sample comprising a mixed cell population.
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机译:一种用于确认包括混合细胞群的血样中可疑靶细胞的检测和计数的方法。
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摘要
a blood sample containing ctcs, or other cells of interest, is labeled with fluorescent markers for image analysis and screened for presence and position within the cartridge of target cells or subcellular elements. A sample containing desired target cells or subcellular elements is then further processed, in part by photobleaching the sample, so that those same targets can be retested with additional biomarkers conjugated to the same or different fluorochromes using the same imaging criteria that were used. for the initial analysis. The present invention has applications with targets such as circulating epithelial cells, circulating tumor cells, circulating endothelial cells, leukocytes, lymphocyte subsets, cells containing an organelle or receptor of interest, cellular debris, disrupted cells and their residues, or any other formed element that could be captured and generate image. The invention provides an additional means of interrogating individual targets of interest, especially when paired with genetic analysis, such as fish.
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