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methods for treating, inhibiting, alleviating or preventing fibrosis, for preventing or reducing kidney damage, for inhibiting progression of chronic kidney disease, for protecting a kidney from kidney injury and for treating a human individual suffering from immunoglobulin a (igan) nephropathy and suffering from membranous nephropathy (mn).
methods for treating, inhibiting, alleviating or preventing fibrosis, for preventing or reducing kidney damage, for inhibiting progression of chronic kidney disease, for protecting a kidney from kidney injury and for treating a human individual suffering from immunoglobulin a (igan) nephropathy and suffering from membranous nephropathy (mn).
In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian patient suffering from or at risk of developing a disease or disorder caused or exacerbated by fibrosis and / or inflammation. . In one embodiment, the invention provides methods of treating an individual suffering from renal fibrosis. In one embodiment, the invention provides methods for reducing proteinuria in an individual suffering from proteinuria-associated renal disease or condition. The methods comprise the step of administering to an individual in need thereof an amount of a masp-2 inhibitory agent effective to inhibit masp-2 dependent complement activation.
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