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process for the preparation of probucol calcogen analogs and their application as a neuroprotective strategy in neurodegenerative processes

机译：普罗布考钙原类似物的制备方法及其在神经退行性过程中作为神经保护策略的应用

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摘要

Process for the preparation of probucol calcogen-analogs and their application as a neuroprotective strategy in neurodegenerative processes The present invention reports the development of organic selenium and sulfur compounds (organocalcogens) analogous to the probucol compound and their use as a neuroprotective strategy in neurodegenerative processes such as such as parkinson's disease, alzheimer's, huntington's, strokes and other neurodegenerative events. specifically reports the synthesis of rc490, rc513, rc363 and rc574 compounds and their use as inhibitors of glutamate and 3-nitropropionic acid-induced neuronal death in ht22 (mouse-derived) immortalized hippocampal neuron cell cultures and the sh-sy5y strain (human neuroblastoma).

机译：普罗布考钙原类似物的制备方法及其在神经退行性过程中作为神经保护策略的应用本发明报道了类似于普罗布考尔化合物的有机硒和硫化合物（有机钙原）的开发及其在神经退行性过程中作为神经保护策略的用途。例如帕金森氏症，老年痴呆症，亨廷顿氏症，中风和其他神经退行性事件。专门报道了rc490，rc513，rc363和rc574化合物的合成及其在ht22（小鼠衍生的）永生海马神经元细胞培养物和sh-sy5y菌株（人类神经母细胞瘤）中谷氨酸和3-硝基丙酸诱导的神经元死亡的抑制剂中的用途。）。

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公开/公告号BR102018008167A2

专利类型
公开/公告日2019-11-05

原文格式PDF
申请/专利权人 UNIVERSIDADE FEDERAL DE SANTA CATARINA;
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申请/专利号BR20181008167
发明设计人 ANTÔNIO LUIZ BRAGA;DIONES CAERAN BUENO;MARCELO FARINA;RÔMULO FARIA SANTOS CANTO;VIVIANE DE SOUZA;
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申请日2018-04-23
分类号A61K31/095;A61K31/05;A61K31/38;A61P25;A61P25/16;A61P25/24;A61P25/28;C07C39/04;C07D333/30;
国家 BR
入库时间 2022-08-21 12:03:40

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