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首页> 外国专利> method for preparing bioprosthetic tissue membrane material, method for making a heart valve leaflet, and method for making a heart valve

method for preparing bioprosthetic tissue membrane material, method for making a heart valve leaflet, and method for making a heart valve

机译：生物修复组织膜材料的制备方法，心脏瓣膜小叶的制备方法以及心脏瓣膜的制备方法

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patent summary: "method for preparing bioprosthetic tissue membrane material, method for making a heart valve leaflet and method for making a heart valve". The present invention relates to methods for conditioning bioprosthetic material employing bovine pericardium membrane. A laser (116, 182) directed at and moved relative to the fibrous surface of the membrane reduces the thickness of the membrane to a specific uniform thickness and smooths the surface. Laser wavelength, energy and pulse rate are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. The thinning may also employ compression. step-wise compression with membrane stabilization is used to prevent membrane damage through inelastic compression. more precisely, the membrane is bound in the elastic compressed state by the addition of crosslinking. As described above, various thinning techniques can be employed together to obtain strong thin membranes. The finally thinned membrane can then be treated by leveling the calcification nucleation sites and reducing boroidide. leaflets (70, 130, 150, 166) may be formed to have more than one region of uniform thickness, such as a thicker peripheral seam region. 20807545v1
机译：专利摘要：“制备生物假体组织膜材料的方法，制备心脏瓣膜小叶的方法和制备心脏瓣膜的方法”。本发明涉及使用牛心包膜调节生物修复材料的方法。对准并相对于膜的纤维表面移动的激光（116、182）将膜的厚度减小至特定的均匀厚度并使表面光滑。选择激光波长，能量和脉冲速率，它们将使纤维表面光滑并烧蚀表面至适当的厚度。或者，使用皮肤刀从膜的纤维表面去除一层材料。细化还可采用压缩。使用具有膜稳定作用的逐步压缩可防止因非弹性压缩而损坏膜。更确切地说，通过交联的添加，膜以弹性压缩状态结合。如上所述，各种稀释技术可以一起使用以获得坚固的薄膜。然后可以通过平整钙化成核位点和还原硼化物来处理最终变薄的膜。小叶（70、130、150、166）可以形成为具有一个以上的均匀厚度的区域，例如较厚的周边接缝区域。 20807545v1

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