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FEATURE SELECTION FOR EFFICIENT EPISTASIS MODELING FOR PHENOTYPE PREDICTION

机译:用于表型预测的有效模型的特征选择

摘要

Various embodiments select markers for modeling epistasis effects. In one embodiment, a processor receives a set of genetic markers and a phenotype. A relevance score is determined with respect to the phenotype for each of the set of genetic markers. A threshold is set based on the relevance score of a genetic marker with a highest relevancy score. A relevance score is determined for at least one genetic marker in the set of genetic markers for at least one interaction between the at least one genetic marker and at least one other genetic marker in the set of genetic markers. The at least one interaction is added to a top-k feature set based on the relevance score of the at least one interaction satisfying the threshold.
机译:各种实施方案选择用于模拟上位效应的标志物。在一个实施方案中,处理器接收一组遗传标记和表型。针对每个遗传标记集的表型确定相关性得分。基于具有最高相关性得分的遗传标记的相关性得分来设置阈值。确定遗传标记集合中的至少一个遗传标记的相关性得分,以用于该遗传标记集合中的至少一个遗传标记和至少一个其他遗传标记之间的至少一个相互作用。基于至少一个满足阈值的交互的相关性得分,将至少一个交互添加到前k个特征集。

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