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ANALOGUES OF PARATHYROID HORMONE (1-34) THAT FUNCTION AS AGONISTS OF THE PARATHYROID HORMONE RECEPTOR-1 AND DISPLAY MODIFIED ACTIVITY PROFILES
ANALOGUES OF PARATHYROID HORMONE (1-34) THAT FUNCTION AS AGONISTS OF THE PARATHYROID HORMONE RECEPTOR-1 AND DISPLAY MODIFIED ACTIVITY PROFILES
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机译:类比拟甲状旁腺激素(1-34)的功能,作为类比拟甲状旁腺激素受体-1并显示修饰的活性特征
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摘要
Described are polypeptide analogs of parathyroid hormone (PTH) that include an unnatural amino acid substitution at positions 7 or 8 from the N-terminus of the polypeptide. Also described are pharmaceutical compositions useful for treating hypoparathyroidism that contain the analogs and methods of using the analogs to treat hypoparathyroidism.
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