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METHOD FOR PREDICTING THE SURVIVAL STATUS AND PROGNOSIS OF ESOPHAGEAL CANCER AND A KIT THEREOF

机译:食管癌生存状况和预后的预测方法及其工具

摘要

The present invention provides a method for determining a survival rate and prognosis state and providing care for a patient having esophageal carcinoma, comprising: (a) providing a tissue sample from the patient; (b) measuring an expression level of a plurality of target genes comprising peptidase inhibitor 3 (PI3) and CD14 in the tissue sample from the patient using reagents specific for a gene product of the plurality of target genes that are selected from the group consisting of probes, primers, antibodies, and antibody fragments, wherein the expression level is measured by RNA expression or protein expression; (c) comparing the expression level of the plurality of target genes to a predetermined threshold indicative of a survival rate and prognosis state for the patient; and (d) providing care for the patient when the survival rate and prognosis state is worse, wherein the care is advising the patent to reduce the time between return visit or to add adjuvant chemotherapy after surgery.
机译:本发明提供了一种确定存活率和预后状态并为患有食管癌的患者提供护理的方法,该方法包括:(a)提供来自患者的组织样品; (b)使用对选自以下的组中的多个靶基因的基因产物具有特异性的试剂,在来自患者的组织样品中测量包含肽酶抑制剂3(PI3)和CD14的多个靶基因的表达水平。探针,引物,抗体和抗体片段,其中表达水平通过RNA表达或蛋白质表达来测量; (c)将多个靶基因的表达水平与指示患者存活率和预后状态的预定阈值进行比较; (d)当存活率和预后状态较差时为患者提供护理,其中该护理建议该专利减少回诊之间的时间或在手术后增加辅助化疗。

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