首页> 外国专利> STRINGS OF EPITOPES USEFUL IN DIAGNOSING AND ELICITING IMMUNE RESPONSES TO SEXUALLY TRANSMITTED INFECTIONS

STRINGS OF EPITOPES USEFUL IN DIAGNOSING AND ELICITING IMMUNE RESPONSES TO SEXUALLY TRANSMITTED INFECTIONS

机译：在诊断和激发对性传播感染的免疫反应中有用的表位

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摘要

Methods and compositions for detecting and diagnosing sexually transmitted infections using a string of epitopes (SOE) specific for detection of causative microorganisms are provided. The antigenic epitopes may be single epitope sequences, a plurality of epitope sequences joined by amino acid linkers to form a series of epitopes (SOE), or nucleotide sequences encoding one or more SOEs and host cells harboring said SOE nucleotide sequences. SOEs specific for highly immunogenic regions of proteins from Trichomonas, Treponema and Neisseria species are provided. SOEs to detect the presence of trichomonas species comprise regions from Trichomonas aldolase, GAPDH, α-enolase and 60 -actinin proteins. Pharmaceutical compositions comprising SOEs can also be used as vaccines or to elicit an immune response to specific microorganisms.

机译：本发明提供了用于检测和诊断性传播感染的方法和组合物，所述方法和组合物使用特异于检测病原微生物的一系列抗原决定簇（SOE）来检测和诊断性传播感染。抗原表位可以是单个表位序列，通过氨基酸接头连接以形成一系列表位（SOE）的多个表位序列，或编码一个或多个SOE的核苷酸序列以及具有所述SOE核苷酸序列的宿主细胞。提供了对滴虫，螺旋体和奈瑟氏球菌物种的高度免疫原性蛋白区域具有特异性的SOE。用于检测毛滴虫物种存在的SOE包括来自毛滴虫醛缩酶，GAPDH，α-烯醇酶和60肌动蛋白的区域。包含SOE的药物组合物也可以用作疫苗或引起对特定微生物的免疫应答。 展开▼

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公开/公告号US2019154689A1

专利类型

公开/公告日2019-05-23

原文格式PDF

申请/专利权人 JOHN F. ALDERETE;
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申请/专利号US201816194589

发明设计人 JOHN F. ALDERETE;
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申请日2018-11-19

分类号G01N33/571;C07K14/44;

国家 US

入库时间 2022-08-21 12:08:56

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