The present disclosure provides systems and methods that leverage machine-learned models in conjunction with online data to monitor and detect the spread of a disease, such as, for example, a communicable illness. In one example, a computing system can include or otherwise leverage a machine-learned disease detection model. The computing system can input search engine data and, optionally, location data respectively associated with a first plurality of users into the machine-learned disease detection model. The computing system can receive identification of a second plurality of users predicted to have the disease as an output of the machine-learned disease detection model. The second plurality of users can be a subset of the first plurality of users. The computing system can identify one or more locations associated with elevated levels of the disease based at least in part on the location data respectively associated with at least the second plurality of users.
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