首页>
外国专利>
METHOD FOR PRODUCING ACTIVE INGREDIENT FOR RIVASTIGMINE FREE BASE TRANSDERMAL PATCH AND RIVASTIGMINE FREE BASE TRANSDERMAL PATCH COMPRISING THE SAME
METHOD FOR PRODUCING ACTIVE INGREDIENT FOR RIVASTIGMINE FREE BASE TRANSDERMAL PATCH AND RIVASTIGMINE FREE BASE TRANSDERMAL PATCH COMPRISING THE SAME
展开▼
机译：制备含有相同成分的利维斯丁碱游离基皮肤斑块和利伐他汀无碱皮肤基斑的活性成分的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides a method for producing an active ingredient for a rivastigmine free base transdermal patch having preparing a rivastigmine free base; and adding an acidic substance to the rivastigmine free base and subjecting the acidic substance and the rivastigmine free base to a mixed reaction to form a mixture having a pH value from 6.0 to 8.5 as the active ingredient; and a rivastigmine free base transdermal patch having a drug layer comprising the active ingredient. The rivastigmine free base transdermal patch has a stable transdermal transmission time equal to or longer than 48 hours and equal to or less than 168 hours. The active ingredient produced by the method and the transdermal patch having the active ingredient allow effective and smooth release of rivastigmine free base and prolongs the release time to meet the clinical application needs.
展开▼
