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GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

机译:恶性胶质瘤中等价脱氢酶和其他基因的遗传改变

摘要

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
机译:我们发现在大多数II级和III级星形细胞瘤和少突胶质细胞瘤以及由这些较低等级病变形成的胶质母细胞瘤中,异柠檬酸脱氢酶1(IDH1)R132残基的突变。那些IDH1中没有突变的肿瘤通常在密切相关的IDH2基因的相似R172残基处发生突变。这些发现对恶性神经胶质瘤的发病机制和诊断具有重要意义。

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