首页> 外国专利> QUENCHERS THAT SLOW, DECREASE, OR INHIBIT THE FORMATION OF CHEMIEXCITATION-INDUCED CYCLOBUTANE PYRIMIDINE DIMERS

QUENCHERS THAT SLOW, DECREASE, OR INHIBIT THE FORMATION OF CHEMIEXCITATION-INDUCED CYCLOBUTANE PYRIMIDINE DIMERS

机译：缓慢，减少或抑制化学激发诱导的环丁烷嘧啶丁形成的猝灭剂

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摘要

A method for decreasing formation of one or more chemiexcitation-induced dark cyclobutane pyrimidine dimers (dCPDs) in a cell or DNA molecule in a subject, who has been exposed to UV radiation, is provided. The method comprises administering to the subject an effective amount of a dCPD quencher within 8 hours after the exposure. The dCPD quencher is selected from the group consisting of ellagic acid, Porphyra Umbilicalis Extract (including Porphyra Umbilicalis Extract (and) Sodium Lactate (and) Lecithin), mycosporine-like amino acids (MAAs) and synthetic analogues thereof, Scutellaria Baicalensis Root Extract, Chrysanthemum Morifolium Leaf Extract, ferulic acid, fused-ring cyanoacrylates, curcumin, epigallocatechin gallate, Scutellaria Baicalensis Root Extract (and) Acacia Catechu Wood Extract, sorbic acid, Polygonum Cuspidatum Root Extract, Acacia Catechu Extract, dipicolinic acid, squalene, Lonicera Japonica (Honeysuckle) Flower Extract, beta-carotene and combinations thereof. The dCPD quencher may be administered to the subject in the absence of UV radiation.

机译：提供了一种减少暴露于紫外线辐射的受试者的细胞或DNA分子中一个或多个化学激发诱导的深色环丁烷嘧啶二聚体（dCPD）的形成的方法。该方法包括在暴露后8小时内向受试者施用有效量的dCPD淬灭剂。 dCPD淬灭剂选自鞣花酸，

紫菜提取物（包括

紫菜 P>提取物（和）乳酸钠（和卵磷脂）），霉菌素样氨基酸（MAA）及其合成类似物，黄cut根根提取物，菊花叶叶提取物，阿魏酸，稠环氰基丙烯酸酯，姜黄素，表没食子儿茶素没食子酸酯，黄S黄ical 根提取物（和）金合欢木材提取物，山梨酸，>虎杖根提取物，金合欢提取物，二吡啶甲酸，角鲨烯，忍冬属植物（金银花）花提取物，β-胡萝卜素及其组合。 dCPD淬灭剂可以在不存在UV辐射的情况下施用于受试者。展开▼

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公开/公告号US2019175679A1

专利类型

公开/公告日2019-06-13

原文格式PDF

申请/专利权人 LOREAL;YALE UNIVERSITY;
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申请/专利号US201715840580

发明设计人 KELLY MARIE GEORGE;ZHI PAN;LAURENT MARROT;MIAO WANG;DOUGLAS EDGAR BRASH;SANJAY PREMI;LETICIA C.P. GONCALVES;
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申请日2017-12-13

分类号A61K36/704;A61K31/366;A61K36/04;A61K47/12;A61K47/24;A61K36/539;A61K36/287;A61K31/192;A61K31/12;A61K31/353;A61K36/48;A61K31/19;A61K31/44;A61K36/355;A61K31/015;A61K31/01;

国家 US

入库时间 2022-08-21 12:12:31

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